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Article

Functional characterization of a human cyclin T1 mutant reveals a different binding surface for Tat and HEXIM1.

Virology - 10 May 2012

Kuzmina Alona, Hadad Uzi, Fujinaga Koh, Taube Ran

Abstract excerpt

HIV transcription is regulated at the step of elongation by the viral Tat protein and the cellular positive transcription elongation factor b (P-TEFb; Cdk9/cyclin T1). Herein, a human cyclin T1 mutant, cyclin T1-U7, which contains four substitutions and one deletion in the N-terminal cyclin box,...

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Share to CD4-Positive T-Lymphocytes
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Protein Structure, Secondary

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Share to tat Gene Products, Human Immunodeficiency Virus

Source

Identifiers

PMID: 22342181
DOI: 10.1016/j.virol.2012.01.033

Genes

HEXIM1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22342181-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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