Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Inhibition of Tat-mediated Transactivation and HIV-1 Replication by Human Anti-hCyclinT1 Intrabodies

1 Jan 2003

Abstract excerpt

Human immunodeficiency virus, type 1 (HIV-1) replication requires the interaction of Tat protein with the human cyclinT1 (hCyclinT1) subunit of the positive transcription elongation factor (P-TEFb) complex, which then cooperatively binds to transactivation response element (TAR) RNA to transactivate HIV transcription. In this report, a non-immune human single-chain antibody (sFv) phage display library was used to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to HIV Research and Treatment
Share to Immune Cell Function and Interaction
Share to Monoclonal and Polyclonal Antibodies Research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Source

Identifiers

PMID: 12401780
DOI: 10.1074/jbc.m208297200

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Inhibition of Tat-mediated Transactivation and HIV-1 Replication by Human Anti-hCyclinT1 IntrabodiesPMID 12401780Read ↗

Functional characterization of a human cyclin T1 mutant reveals a different binding surface for Tat and HEXIM1.Semantic proximity Read ↗

Inhibition of HIV‐1 Tat‐mediated LTR transactivation and HIV‐1 infection by anti‐Tat single chain intrabodies.Semantic proximity Read ↗

Dominant negative mutant cyclin T1 proteins inhibit HIV transcription by specifically degrading Tat.Semantic proximity Read ↗

Dominant negative mutant cyclin T1 proteins that inhibit HIV transcription by forming a kinase inactive complex with Tat.Semantic proximity Read ↗

HIV Tat/P-TEFb Interaction: A Potential Target for Novel Anti-HIV TherapiesSemantic proximity Read ↗

A mutant Tat protein provides strong protection from HIV-1 infection in human CD4+ T cells.Semantic proximity Read ↗

Development of an Attenuated Tat Protein as a Highly-effective Agent to Specifically Activate HIV-1 Latency.Semantic proximity Read ↗

Regulation of CD4 expression via recycling by HRES-1/RAB4 controls susceptibility to HIV infection.Semantic proximity Read ↗

Shutdown of HIV-1 Transcription in T Cells by Nullbasic, a Mutant Tat ProteinSemantic proximity Read ↗

Modifications in the human T cell proteome induced by intracellular HIV-1 Tat protein expressionSemantic proximity Read ↗

Identification of Alternatively Translated Tetherin Isoforms with Differing Antiviral and Signaling ActivitiesSemantic proximity Read ↗

A transdominant tat mutant that inhibits tat-induced gene expression from the human immunodeficiency virus long terminal repeat.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.