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Human Immunodeficiency Virus Type 1 Infection Induces Cyclin T1 Expression in Macrophages

14 Jul 2004

Abstract excerpt

The Tat protein of human immunodeficiency virus type 1 (HIV-1) is essential for viral replication and activates RNA polymerase II transcriptional elongation through the association with a cellular protein kinase composed of Cdk9 and cyclin T1. Tat binds to this kinase complex through a direct protein-protein interaction with cyclin T1. Monocytes/macrophages are important targets of HIV-1 infection, and previous...

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PMID: 15254183
DOI: 10.1128/jvi.78.15.8114-8119.2004

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