Article
Life span extension by dietary restriction is reduced but not abolished by loss of both SIR2 and HST2 in Podospora anserina.
Mechanisms of ageing and development - 1 Dec 2008
Boivin Antoine, Gaumer Sébastien, Sainsard-Chanet Annie
Abstract excerpt
Dietary restriction (DR) extends life span of many organisms, from yeast to mammals. The question of whether or not the SIR2 protein functions to mediate life span extension in response to DR remains debated. In this paper, we studied the relationship between SIR2 and DR in the filamentous fungus Podospora anserina. We show that the loss of PaSir2, PaHst2 or PaPnc1 does not alter life span under standard...
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