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Article

Overexpression of Sir2 in the adult fat body is sufficient to extend lifespan of male and female Drosophila

29 Apr 2013

Abstract excerpt

Sir2 is the most intensively discussed longevity gene in current aging research. Although, the gene encoding a NAD(+)-dependent histone deacetylase initially was found to extend lifespan of various organisms ranging from yeast to mammals, serious doubts regarding its role in longevity have been expressed recently. In this study, we tested whether tissue-specific overexpression of Sir2 in the adult fat body can...

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PMID: 23765091
DOI: 10.18632/aging.100553

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