Article
CTCF regulates cell cycle progression of alphabeta T cells in the thymus.
The EMBO journal - 5 Nov 2008
Heath Helen, Ribeiro de Almeida Claudia, Sleutels Frank, Dingjan Gemma, van de Nobelen Suzanne, Jonkers Iris, Ling Kam-Wing, Gribnau Joost, Renkawitz Rainer, Grosveld Frank, Hendriks Rudi W, Galjart Niels
Abstract excerpt
The 11-zinc finger protein CCCTC-binding factor (CTCF) is a highly conserved protein, involved in imprinting, long-range chromatin interactions and transcription. To investigate its function in vivo, we generated mice with a conditional Ctcf knockout allele. Consistent with a previous report, we find that ubiquitous ablation of the Ctcf gene results in early embryonic lethality. Tissue-specific inactivation of...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.