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Article

CTCF contributes in a critical way to spermatogenesis and male fertility

27 Jun 2016

Abstract excerpt

The CCCTC-binding factor (CTCF) is an architectural protein that governs chromatin organization and gene expression in somatic cells. Here, we show that CTCF regulates chromatin compaction necessary for packaging of the paternal genome into mature sperm. Inactivation of Ctcf in male germ cells in mice (Ctcf-cKO mice) resulted in impaired spermiogenesis and infertility. Residual spermatozoa in Ctcf-cKO mice...

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PMID: 27345455
DOI: 10.1038/srep28355

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