OmpB (osmo-regulation) and icsA (cell-to-cell spread) mutants of Shigella flexneri: vaccine candidates and probes to study the pathogenesis of shigellosis.

doi:10.1016/0264-410x(91)90128-s

Back to search

Article

OmpB (osmo-regulation) and icsA (cell-to-cell spread) mutants of Shigella flexneri: vaccine candidates and probes to study the pathogenesis of shigellosis.

Vaccine - 1 Jun 1991

Sansonetti P J, Arondel J, Fontaine A, d'Hauteville H, Bernardini M L

Abstract excerpt

Genetic and molecular data now available on the pathogenic properties of Shigella flexneri allow rational design of live attenuated vaccine strains. The genes required at given steps of the infection process can be selectively mutated to impair the bacterium's capacity to interact with intestinal...

Topics

Animals
Antibodies, Bacterial
Bacterial Vaccines
Dysentery, Bacillary
Female
Genes, Bacterial
Macaca mulatta
Male
Mutation
Shigella flexneri

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

discussions

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.