Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

The virulence domain of Shigella IcsA contains a subregion with specific host cell adhesion function.

PloS one - 1 Jan 2020

Qin Jilong, Doyle Matthew Thomas, Tran Elizabeth Ngoc Hoa, Morona Renato

Abstract excerpt

Shigella species cause bacillary dysentery, especially among young individuals. Shigellae target the human colon for invasion; however, the initial adhesion mechanism is poorly understood. The Shigella surface protein IcsA, in addition to its role in actin-based motility, acts as a host cell adhesin through unknown mechanism(s). Here we confirmed the role of IcsA in cell adhesion and defined the region required...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adhesins, Bacterial
Share to Bacterial Proteins
Share to Cell Adhesion

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Dysentery, Bacillary

Share to Host Microbial Interactions

Share to Mutagenesis

Share to Shigella flexneri

Source

Open in PubMed Open full text

Identifiers

PMID: 31910229
DOI: 10.1371/journal.pone.0227425
PMCID: PMC6946128

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

The virulence domain of Shigella IcsA contains a subregion with specific host cell adhesion function.PMID 31910229Read ↗

Disruption of IcsP, the major Shigella protease that cleaves IcsA, accelerates actin-based motility.Semantic proximity Read ↗

A system for identifying post-invasion functions of invasion genes: requirements for the Mxi-Spa type III secretion pathway of Shigella flexneri in intercellular dissemination.Semantic proximity Read ↗

Absence of O antigen suppresses Shigella flexneri IcsA autochaperone region mutations.Semantic proximity Read ↗

Escape of intracellular Shigella from autophagy requires binding to cholesterol through the type III effector, IcsB.Semantic proximity Read ↗

Multicopy icsA is able to suppress the virulence defect caused by the wzz(SF) mutation in Shigella flexneri.Semantic proximity Read ↗

icsB: a Shigella flexneri virulence gene necessary for the lysis of protrusions during intercellular spread.Semantic proximity Read ↗

Shigella flexneri cell-to-cell spread, and growth and inflammation in mice, is limited by the outer membrane protease IcsP.Semantic proximity Read ↗

Identification of Shigella flexneri IcsA residues affecting interaction with N-WASP, and evidence for IcsA-IcsA co-operative interaction.Semantic proximity Read ↗

Identification of functional regions within invasion plasmid antigen C (IpaC) of Shigella flexneri.Semantic proximity Read ↗

Topology and contribution to the pore channel lining of plasma membrane-embedded <i>S. flexneri</i> type 3 secretion translocase IpaBSemantic proximity Read ↗

Role of Pilus Proteins in Adherence and Invasion of Streptococcus agalactiae to the Lung and Cervical Epithelial CellsSemantic proximity Read ↗

[Functional analysis of IcsB protein secreted via the type III secretion system of Shigella].Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.