Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic modulation of Shigella flexneri 2a lipopolysaccharide O antigen modal chain length reveals that it has been optimized for virulence.

Microbiology (Reading, England) - 1 Apr 2003

Morona Renato, Daniels Craig, Van Den Bosch Luisa

Abstract excerpt

The lipopolysaccharide (LPS) molecules of Shigella flexneri 2a have O antigen (Oag) polysaccharides with two modal chain length distributions. The chromosomal wzz(SF) gene results in short (S) type Oag chains [11-17 Oag repeat units (RUs)], and the pHS-2 plasmid-located wzz(pHS2) gene results in very long (VL) type Oag chains (>90 Oag RUs). S. flexneri wzz(SF) mutants are unable to form plaques on HeLa cell...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Actins
Share to Cricetinae
Share to Dysentery, Bacillary

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Fluorescent Antibody Technique

Share to Guinea Pigs

Share to HeLa Cells

Share to O Antigens

Share to Shigella flexneri

Source

Identifiers

PMID: 12686635
DOI: 10.1099/mic.0.26141-0

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic modulation of Shigella flexneri 2a lipopolysaccharide O antigen modal chain length reveals that it has been optimized for virulence.PMID 12686635Read ↗

Multicopy icsA is able to suppress the virulence defect caused by the wzz(SF) mutation in Shigella flexneri.Semantic proximity Read ↗

Relationship between O-antigen chain length and resistance to colicin E2 in Shigella flexneri.Semantic proximity Read ↗

Mutational analysis of the Shigella flexneri O-antigen polymerase Wzy: identification of Wzz-dependent Wzy mutants.Semantic proximity Read ↗

Structural and Biochemical Analysis of a Single Amino-Acid Mutant of WzzBSF That Alters Lipopolysaccharide O-Antigen Chain Length in Shigella flexneri.Semantic proximity Read ↗

Nucleotide sequence of the rhamnose biosynthetic operon of Shigella flexneri 2a and role of lipopolysaccharide in virulence.Semantic proximity Read ↗

Effect of mutations in Shigella flexneri chromosomal and plasmid-encoded lipopolysaccharide genes on invasion and serum resistance.Semantic proximity Read ↗

Mutational analysis of the major periplasmic loops of Shigella flexneri Wzy: identification of the residues affecting O antigen modal chain length control, and Wzz-dependent polymerization activity.Semantic proximity Read ↗

Identification of a Region in Shigella flexneri WzyB Disrupting the Interaction with WzzpHS2.Semantic proximity Read ↗

Effect of the O-antigen length of lipopolysaccharide on the functions of Type III secretion systems in Salmonella enterica.Semantic proximity Read ↗

Activation of the Type VI Secretion System in the Squid Symbiont Vibrio fischeri Requires the Transcriptional Regulator TasR and the Structural Proteins TssM and TssA.Semantic proximity Read ↗

A Shigella flexneri virulence plasmid encoded factor controls production of outer membrane vesicles.Semantic proximity Read ↗

The Wzy O-antigen polymerase of Yersinia pseudotuberculosis O:2a has a dependence on the Wzz chain-length determinant for efficient polymerization.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.