Article
Construction and evaluation of live attenuated vaccine strains of Shigella flexneri and Shigella dysenteriae 1.
Research in microbiology - 1 Jan 2000
Fontaine A, Arondel J, Sansonetti P J
Abstract excerpt
Shigellosis is an invasive disease of the human colon which is particularly prevalent among children of the developing world. No proper vaccine is available to protect against this enteric disease. It is currently accepted that only live strains with attenuated virulence administered orally may elicit protective immunity at the level of the colonic mucosa, which is the exclusive site of multiplication of...
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