Article
Alternative methods of attenuating Salmonella species for potential vaccine use.
Research in microbiology - 1 Jan 2000
Wilson D R, Chatfield S, Betts J, Griffiths A, Leung K Y, Dougan G, Finlay B B
Abstract excerpt
Because of their invasive properties, Salmonella species are uniquely suited for use as live oral vaccines, and mutants attenuated in general metabolic functions show promise as vaccine strains. We have identified a Salmonella choleraesuis transposon mutant which is deficient in abilities to atta...
Topics
- Animals
- Bacterial Vaccines
- DNA Transposable Elements
- Mice
- Mice, Inbred BALB C
- Mutation
- Salmonella
- Vaccines, Attenuated
- Vaccines, Synthetic