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Article

icsB: a Shigella flexneri virulence gene necessary for the lysis of protrusions during intercellular spread.

Molecular microbiology - 1 Jun 1992

Allaoui A, Mounier J, Prévost M C, Sansonetti P J, Parsot C

Abstract excerpt

Shigella flexneri causes bacillary dysentery by invading epithelial cells of the colonic mucosa. We have characterized the icsB gene which is located on the virulence plasmid pWR100. After inactivation of icsB, the mutant strain remained invasive, but formed abnormally small plaques on HeLa cell monolayers, colonized only the peripheral cells of Caco-2 islets, and was unable to provoke a keratoconjunctivitis in...

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Identifiers

PMID: 1495389
DOI: 10.1111/j.1365-2958.1992.tb00885.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Research trail→

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icsB: a Shigella flexneri virulence gene necessary for the lysis of protrusions during intercellular spread.PMID 1495389Read ↗

Shigella flexneri cell-to-cell spread, and growth and inflammation in mice, is limited by the outer membrane protease IcsP.Semantic proximity Read ↗

IpaB of Shigella flexneri causes entry into epithelial cells and escape from the phagocytic vacuole.Semantic proximity Read ↗

Disruption of IcsP, the major Shigella protease that cleaves IcsA, accelerates actin-based motility.Semantic proximity Read ↗

The virulence domain of Shigella IcsA contains a subregion with specific host cell adhesion function.Semantic proximity Read ↗

Multicopy icsA is able to suppress the virulence defect caused by the wzz(SF) mutation in Shigella flexneri.Semantic proximity Read ↗

Phosphorylation of IcsA by cAMP-dependent protein kinase and its effect on intracellular spread of Shigella flexneri.Semantic proximity Read ↗

Genetic and Molecular Basis of Epithelial Cell Invasion by Shigella SpeciesSemantic proximity Read ↗

A translocation-competent pore is required for <i>Shigella flexneri</i> to escape from the double membrane vacuole during intercellular spreadSemantic proximity Read ↗

A system for identifying post-invasion functions of invasion genes: requirements for the Mxi-Spa type III secretion pathway of Shigella flexneri in intercellular dissemination.Semantic proximity Read ↗

The development of a FACS-based strategy for the isolation of Shigella flexneri mutants that are deficient in intercellular spread.Semantic proximity Read ↗

Actin-based motility is sufficient for bacterial membrane protrusion formation and host cell uptake.Semantic proximity Read ↗

Identification of Shigella flexneri IcsA residues affecting interaction with N-WASP, and evidence for IcsA-IcsA co-operative interaction.Semantic proximity Read ↗

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