Article
Shigella flexneri cell-to-cell spread, and growth and inflammation in mice, is limited by the outer membrane protease IcsP.
FEMS microbiology letters - 1 Jun 2015
Tran Elizabeth Ngoc Hoa, Attridge Stephen R, Teh Min Yan, Morona Renato
Abstract excerpt
The Shigella flexneri autotransporter protein IcsA is essential for intra- and intercellular spread, and icsA mutants are attenuated in several models. However, the pathogenic significance of the outer membrane protease IcsP, which orchestrates the polar distribution of IcsA on the bacterial surface, remains unclear. To further examine this point, we constructed icsP mutants in the two most commonly studied S....
Topics
- Actins
- Aminoglycosides
- Animals
- Bacterial Outer Membrane Proteins
- Bacterial Proteins
- Caco-2 Cells
- Cell Line
- DNA-Binding Proteins
- Dysentery, Bacillary
- HeLa Cells
- Humans
- Male
- Mice
- Mice, Inbred BALB C
- Mutation
- Shigella flexneri
- Transcription Factors