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Article

Vaccination against Shigellosis with Attenuated <i>Shigella flexneri</i> 2a Strain SC602

1 Jul 1999

Abstract excerpt

The Shigella flexneri 2a SC602 vaccine candidate carries deletions of the plasmid-borne virulence gene icsA (mediating intra- and intercellular spread) and the chromosomal locus iuc (encoding aerobactin) (S. Barzu, A. Fontaine, P. J. Sansonetti, and A. Phalipon, Infect. Immun. 64:1190-1196, 1996). Dose selection studies showed that SC602 causes shigellosis in a majority of volunteers when 3 x 10(8) or 2 x 10(6)...

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Identifiers

PMID: 10377124
DOI: 10.1128/iai.67.7.3437-3443.1999

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