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Article

Disruption of IcsP, the major Shigella protease that cleaves IcsA, accelerates actin-based motility.

Molecular microbiology - 1 Aug 1997

Shere K D, Sallustio S, Manessis A, D'Aversa T G, Goldberg M B

Abstract excerpt

Shigella pathogenesis involves bacterial invasion of colonic epithelial cells and movement of bacteria through the cytoplasm and into adjacent cells by means of actin-based motility. The Shigella protein IcsA (VirG) is unipolar on the bacterial surface and is both necessary and sufficient for actin-based motility. IcsA is inserted into the outer membrane as a 120-kDa polypeptide that is subsequently slowly...

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PMID: 9302008
DOI: 10.1046/j.1365-2958.1997.4681827.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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Disruption of IcsP, the major Shigella protease that cleaves IcsA, accelerates actin-based motility.PMID 9302008Read ↗

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