Article
Differential sensitivity of human colonic adenoma and carcinoma cells to transforming growth factor beta (TGF-beta): conversion of an adenoma cell line to a tumorigenic phenotype is accompanied by a reduced response to the inhibitory effects of TGF-beta.
Oncogene - 1 Aug 1991
Manning A M, Williams A C, Game S M, Paraskeva C
Abstract excerpt
The growth of three non-tumorigenic human colonic adenoma cell lines, designated AA/C1, RG/C2 and RR/C1, was inhibited by low concentrations of transforming growth factor beta (TGF-beta) (0.05-0.5 ng ml-1). However, the growth of five human colon cancer cell lines under identical conditions was r...
Topics
- Adenoma
- Carcinoma
- Cell Line, Transformed
- Cell Transformation, Neoplastic
- Colorectal Neoplasms
- Dose-Response Relationship, Drug
- Drug Resistance
- Genes, ras
- Humans
- Mutation
- Phenotype
- Precancerous Conditions
- Transforming Growth Factor beta
- Tumor Cells, Cultured