Article
The capacity for growth stimulation by TGF beta 1 seen only in advanced colon cancers cannot be ascribed to mutations in APC, DCC, p53 or ras.
Oncogene - 1 Dec 1994
Huang F, Hsu S, Yan Z, Winawer S, Friedman E
Abstract excerpt
Human colon cancer development is associated with the accumulation of mutations and deletions in the suppressor genes DCC, APC and p53 and mutations in the dominant oncogene K-ras, with loss of wild type alleles. In earlier studies we had observed that about half of the resected human colon cancers placed into primary culture were growth stimulated by TGF beta 1. This group included the more advanced cancers...
Topics
- Base Sequence
- Cell Division
- Colonic Neoplasms
- Genes, APC
- Genes, DCC
- Genes, Tumor Suppressor
- Genes, p53
- Genes, ras
- Humans
- Molecular Sequence Data
- Mutation