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Article

TGF-beta1 in colonic neoplasia: a genetic molecular and immunohistochemical study.

Journal of experimental & clinical cancer research : CR - 1 Sept 1997

Cardillo M R, Yap E

Abstract excerpt

Transforming growth factor-beta proteins are key regulators of cellular growth and differentiation. To understand the role of TGF-beta in colonic tumour progression, 47 paraffin embedded samples from colonic tumours (13 adenomas, and 34 adenocarcinomas) were studied. Gene mutations in the region coding for the active protein were studied by PCR SSCP analysis of exons 5, 6, and 7. TGF-beta1 mRNA expression and...

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PMID: 9387902

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

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