Article
Resistance to high concentrations of methotrexate and 5-fluorouracil of differentiated HT-29 colon-cancer cells is restricted to cells of enterocytic phenotype.
International journal of cancer - 4 May 1998
Lesuffleur T, Violette S, Vasile-Pandrea I, Dussaulx E, Barbat A, Muleris M, Zweibaum A
Abstract excerpt
Adaptation of HT-29 cells to increasing concentrations of methotrexate (MTX) results in the selection of differentiated populations which show sequential dose-dependent changes of their differentiated phenotype with, at the highest concentrations (0.1 and 1 mM), a shift of differentiation from a...
Topics
- Antimetabolites, Antineoplastic
- Cell Differentiation
- Drug Resistance, Multiple
- Drug Resistance, Neoplasm
- Fluorouracil
- HT29 Cells
- Humans
- Methotrexate
- Phenotype
- Tetrahydrofolate Dehydrogenase