Article
Novel cell culture model for prevention of carcinogenic risk in familial adenomatous polyposis syndrome.
Oncology reports - 1 Apr 2009
Telang Nitin, Katdare Meena
Abstract excerpt
Clinical familial adenomatous polyposis (FAP) syndrome represents a high risk pre-invasive precursor for colon cancer, and is characterized by germ line mutation in the adenomatous polyposis coli (APC) tumor suppressor gene. Cellular models with relevant genetic and biological characteristics should provide important mechanistic leads for predisposition and preventive intervention. Cloned colon epithelial cell...
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