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Article

The role of growth regulatory aberrations in progression of human colon carcinoma.

Cancer metastasis reviews - 1 Sept 1993

Howell G M, Sun L, Ziober B L, Wu S P, Brattain M G

Abstract excerpt

Colon carcinoma is a multistage disease. Most malignancies arise from pre-existing benign tumors. Multiple chromosomal defects affecting oncogene and tumor suppressor gene function are associated with disease progression. These aberrations result in an imbalance between the normal positive and negative growth effectors, which contribute further to disease progression. We have studied how changes in the expression...

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PMID: 8281613
DOI: 10.1007/BF00665958

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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