Article
Specific cytogenetic abnormalities and k-ras mutation in two new human colorectal-adenoma-derived cell lines.
International journal of cancer - 11 Nov 1992
Williams A C, Harper S J, Marshall C J, Gill R W, Mountford R A, Paraskeva C
Abstract excerpt
Two new human epithelial cell lines from sporadic colorectal adenomas designated S/RR and S/BR are reported. Both cell lines have extended growth capacities in vitro, reaching passages 38 and 40 respectively and show no sign of senescence. S/RR and S/BR cell lines have retained the ability to dif...
Topics
- Adenoma
- Base Sequence
- Chromosome Aberrations
- Chromosome Disorders
- Colorectal Neoplasms
- Genes, ras
- Humans
- Karyotyping
- Molecular Sequence Data
- Mutation
- Oligodeoxyribonucleotides
- Polymerase Chain Reaction
- Proto-Oncogene Proteins p21(ras)
- Tumor Cells, Cultured