Article
Transfection and expression of mutant p53 protein does not alter the in vivo or in vitro growth characteristics of the AA/C1 human adenoma derived cell line, including sensitivity to transforming growth factor-beta 1.
Oncogene - 1 May 1994
Williams A C, Browne S J, Manning A M, Daffada P, Collard T J, Paraskeva C
Abstract excerpt
Mutation of the p53 gene is thought to be a late event in human colorectal carcinogenesis, involved in the malignant conversion of the adenoma to the carcinoma. One of the questions that we hoped to address was whether, in vivo, a single mutational event in one p53 gene is sufficient to confer a significant growth advantage on a colonic epithelial cell. Such a growth advantage could result either from an increase...
Topics
- Adenoma
- Animals
- Cell Division
- Colonic Neoplasms
- DNA, Neoplasm
- Humans
- Mice
- Mice, Nude
- Mutation
- Neoplasm Transplantation
- Phenotype