Article
Mutant p53 is not fully dominant over endogenous wild type p53 in a colorectal adenoma cell line as demonstrated by induction of MDM2 protein and retention of a p53 dependent G1 arrest after gamma irradiation.
Oncogene - 6 Jul 1995
Williams A C, Miller J C, Collard T J, Bracey T S, Cosulich S, Paraskeva C
Abstract excerpt
To determine whether a single mutational event in one p53 gene is sufficient to confer a significant growth advantage on a colonic epithelial cell, the 143(Ala) p53 mutation was previously expressed in the human colonic adenoma derived cell line AA/C1 (which is wild type for p53) and shown to have no effect on it's in vitro or in vivo growth characteristics. In this investigation, by expressing the 175(His),...
Topics
- Adenoma
- Base Sequence
- Cell Division
- Colorectal Neoplasms
- DNA Primers
- G1 Phase
- Gamma Rays
- Genes, Dominant
- Genes, p53
- Humans
- Molecular Sequence Data