A benign cultured colon adenoma bears three genetically altered colon cancer oncogenes, but progresses to tumorigenicity and transforming growth factor-beta independence without inactivating the p53 tumor suppressor gene.

doi:10.1172/JCI117048

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Article

A benign cultured colon adenoma bears three genetically altered colon cancer oncogenes, but progresses to tumorigenicity and transforming growth factor-beta independence without inactivating the p53 tumor suppressor gene.

The Journal of clinical investigation - 1 Mar 1994

Markowitz S D, Myeroff L, Cooper M J, Traicoff J, Kochera M, Lutterbaugh J, Swiriduk M, Willson J K

Abstract excerpt

We describe the spontaneous progression of a colon adenoma cell line to tumorigenicity and growth factor independence. This system allows direct comparison of biologic stages of malignant progression with alterations of colon cancer suppressor genes and oncogenes. VACO-235, a human colon adenoma...

Topics

Adenoma
Animals
Base Sequence
Cell Division
Chromosome Aberrations
Colonic Neoplasms
Female
Genes, p53
Humans
Mice
Mice, Inbred BALB C
Molecular Sequence Data
Mutation
Oncogenes

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Transforming Growth Factor beta

Tumor Cells, Cultured

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Identifiers

PMID: 8132740
DOI: 10.1172/JCI117048
PMCID: PMC294021

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 30 Aug 2026. Prepared record publication-8132740-2026-08-30.1. Manifest publication-graph-cohort-2026-08-30.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 30 Aug 2026.