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Article

The influence of type I collagen on the growth and differentiation of the human colonic adenocarcinoma cell line HT-29 in vitro.

Differentiation; research in biological diversity - 1 Aug 1992

East J A, Langdon S P, Townsend K M, Hickman J A

Abstract excerpt

HT-29 Human colonic adenocarcinoma cells when grown on a plastic substratum were anaplastic in appearance and failed to express any morphological or biochemical features that were characteristic of intestinal differentiation. Growth of HT-29 cells subcutaneously in the flank of immune deprived mice gave rise to morphologically heterogeneous tumors which were poorly differentiated but contained approximately 11%...

Topics

Adenocarcinoma
Alkaline Phosphatase
Aminopeptidases
Animals
Carcinoembryonic Antigen
Cell Division
Cell Transformation, Neoplastic
Collagen
Colonic Neoplasms
Enzyme-Linked Immunosorbent Assay

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Humans

Mice

Mice, Nude

Microscopy, Electron

Microscopy, Electron, Scanning

Phenotype

Time Factors

Transplantation, Heterologous

Source

Identifiers

PMID: 1426702
DOI: 10.1111/j.1432-0436.1992.tb00672.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1426702-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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