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Article

Germline genetic variations in drug action pathways predict clinical outcomes in advanced lung cancer treated with platinum-based chemotherapy.

Pharmacogenetics and genomics - 1 Nov 2008

Wu Xifeng, Lu Charles, Ye Yuanqing, Chang Joe, Yang Hushan, Lin Jie, Gu Jian, Hong Waun Ki, Stewart David, Spitz Margaret R

Abstract excerpt

PURPOSE: Genetic polymorphisms contribute to interindividual variation in drug response. However, a single polymorphism is likely to exhibit a modest effect. Therefore, we applied a pathway-based approach to evaluate the cumulative effect of multiple polymorphisms on clinical outcome of patients with non-small cell lung cancer. METHODS: We genotyped 25 functional polymorphisms in 16 key genes involved in...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 18854777
DOI: 10.1097/FPC.0b013e32830efdd4
PMCID: PMC2665725

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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