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Article

Genetic variations in multiple drug action pathways and survival in advanced stage non-small cell lung cancer treated with chemotherapy.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Jun 2011

Li Yafei, Sun Zhifu, Cunningham Julie M, Aubry Marie C, Wampfler Jason A, Croghan Gary A, Johnson Cassandra, Wu Danli, Aakre Jeremiah A, Molina Julian, Wang Liewei, Pankratz V Shane, Yang Ping

Abstract excerpt

PURPOSE: Variations in genes related to biological activity of anticancer drugs could influence treatment responses and lung cancer prognosis. Genetic variants in four biological pathways, that is, glutathione metabolism, DNA repair, cell cycle, and epidermal growth factor receptor (EGFR), were systematically investigated to examine their association with survival in advanced stage non-small cell lung cancer...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 21636554
DOI: 10.1158/1078-0432.CCR-10-2877
PMCID: PMC3124814

Genes

EGFR
RAF1
GPX5
GPX7
GSS
NRAS

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