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Article

Genetic variations in radiation and chemotherapy drug action pathways predict clinical outcomes in esophageal cancer.

Journal of clinical oncology : official journal of the American Society of Clinical Oncology - 10 Aug 2006

Wu Xifeng, Gu Jian, Wu Tsung-Teh, Swisher Stephen G, Liao Zhongxin, Correa Arlene M, Liu Jun, Etzel Carol J, Amos Christopher I, Huang Maosheng, Chiang Silvia S, Milas Luke, Hittelman Walter N, Ajani Jaffer A

Abstract excerpt

PURPOSE: Understanding how specific genetic variants modify drug action pathways may provide informative blueprints for individualized chemotherapy. METHODS: We applied a pathway-based approach to examine the impact of a comprehensive panel of genetic polymorphisms on clinical outcomes in 210 esophageal cancer patients. RESULTS: In the Cox proportional hazards model, MTHFR Glu429Ala variant genotypes were...

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Source

Identifiers

PMID: 16785472
DOI: 10.1200/JCO.2005.03.6640

Genes

MTHFR
XRCC1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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