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Potentially functional variants in nucleotide excision repair pathway genes predict platinum treatment response of Chinese ovarian cancer patients.

Carcinogenesis - 24 Sept 2020

Li Haoran, Dai Hongji, Shi Tingyan, Cheng Xi, Sun Menghong, Chen Kexin, Wang Mengyun, Wei Qingyi

Abstract excerpt

Acquired platinum resistance impedes successful treatment of epithelial ovarian cancer (EOC), and this resistance may be associated with inherited DNA damage-repair response. In the present study, we performed a two-phase analysis to assess associations between 8191 single-nucleotide polymorphisms within 127 genes of nucleotide excision repair pathway from a genome-wide association study dataset and platinum...

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Biomarkers, Tumor
Cell Cycle Proteins
Cystadenocarcinoma, Serous
Follow-Up Studies
Gene Expression Regulation, Neoplastic

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ovarian Neoplasms

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PMID: 32663249
DOI: 10.1093/carcin/bgaa075

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