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Article

Genetic variation in the DNA repair genes is predictive of outcome in lung cancer.

Human molecular genetics - 1 Oct 2007

Matakidou Athena, el Galta Rachid, Webb Emily L, Rudd Matthew F, Bridle Helen, Eisen Tim, Houlston Richard S

Abstract excerpt

To assess whether DNA repair gene variants influence the clinical behaviour of lung cancer we examined the impact of a comprehensive panel of 109 non-synonymous single-nucleotide polymorphisms (nsSNPs) in 50 DNA repair genes on overall survival (OS) in 700 lung cancer patients. Fifteen nsSNPs wer...

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Source

Identifiers

PMID: 17855454
DOI: 10.1093/hmg/ddm190

Genes

ERCC6
EXO1
APEX1
BRCA2
ERCC5
POLB
POLE

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026. Prepared record publication-17855454-2026-09-02.2. Manifest publication-graph-cohort-2026-09-02.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 2 Sept 2026.

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