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Article

Pharmacogenetics of the DNA repair pathways in advanced non-small cell lung cancer patients treated with platinum-based chemotherapy.

Cancer letters - 28 Oct 2014

Sullivan Ivana, Salazar Juliana, Majem Margarita, Pallarés Cinta, Del Río Elisabeth, Páez David, Baiget Montserrat, Barnadas Agustí

Abstract excerpt

Genetic variants in DNA repair genes may play a role in the effectiveness of platinum-based chemotherapy in non-small cell lung cancer (NSCLC). We analyzed 17 SNPs in eight genes (ERCC1, ERCC2, ERCC3, ERCC4, ERCC5, XPA, XRCC1 and XRCC2) involved in DNA repair mechanisms and its association with outcome in NSCLC. This prospective study included patients with stages III and IV treated with platinum-based...

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Source

Identifiers

PMID: 25069034
DOI: 10.1016/j.canlet.2014.07.023

Genes

ERCC1
ERCC2
ERCC3
ERCC4
XRCC1
ERCC5
XPA
XRCC2

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Pharmacogenetics of the DNA repair pathways in advanced non-small cell lung cancer patients treated with platinum-based chemotherapy.PMID 25069034Read ↗

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