Genome-wide association study of survival in non-small cell lung cancer patients receiving platinum-based chemotherapy.

doi:10.1093/jnci/djr075

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Article

Genome-wide association study of survival in non-small cell lung cancer patients receiving platinum-based chemotherapy.

Journal of the National Cancer Institute - 18 May 2011

Wu Xifeng, Ye Yuanqing, Rosell Rafael, Amos Christopher I, Stewart David J, Hildebrandt Michelle A T, Roth Jack A, Minna John D, Gu Jian, Lin Jie, Buch Shama C, Nukui Tomoko, Ramirez Serrano Jose Luis, Taron Miquel, Cassidy Adrian, Lu Charles, Chang Joe Y, Lippman Scott M, Hong Waun Ki, Spitz Margaret R, Romkes Marjorie, Yang Ping

Abstract excerpt

BACKGROUND: Interindividual variation in genetic background may influence the response to chemotherapy and overall survival for patients with advanced-stage non-small cell lung cancer (NSCLC). METHODS: To identify genetic variants associated with poor overall survival in these patients, we conducted a genome-wide scan of 307,260 single-nucleotide polymorphisms (SNPs) in 327 advanced-stage NSCLC patients who...

Topics

Adult
Aged
Aged, 80 and over
Antineoplastic Combined Chemotherapy Protocols
Area Under Curve
Carcinoma, Non-Small-Cell Lung
Chemotherapy, Adjuvant
Female

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Genome-Wide Association Study

Genotype

Humans

Kaplan-Meier Estimate

Linkage Disequilibrium

Lung Neoplasms

Male

Middle Aged

Multivariate Analysis

Neoplasm Staging

Source

Open in PubMed Open full text

Identifiers

PMID: 21483023
DOI: 10.1093/jnci/djr075
PMCID: PMC3096796

Genes

CMKLR1

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

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