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Article

The coordinated functions of the E. coli MutS and MutL proteins in mismatch repair.

Molecular cell - 1 Jul 2003

Acharya Samir, Foster Patricia L, Brooks Peter, Fishel Richard

Abstract excerpt

The Escherichia coli MutS and MutL proteins have been conserved throughout evolution, although their combined functions in mismatch repair (MMR) are poorly understood. We have used biochemical and genetic studies to ascertain a physiologically relevant mechanism for MMR. The MutS protein functions as a regional lesion sensor. ADP-bound MutS specifically recognizes a mismatch. Repetitive rounds of...

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Identifiers

PMID: 12887908
DOI: 10.1016/s1097-2765(03)00219-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The coordinated functions of the E. coli MutS and MutL proteins in mismatch repair.PMID 12887908Read ↗

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