Article
The molecular mechanism of DNA damage recognition by MutS homologs and its consequences for cell death response.
Nucleic acids research - 1 Jan 2006
Salsbury Freddie R, Clodfelter Jill E, Gentry Michael B, Hollis Thomas, Scarpinato Karin Drotschmann
Abstract excerpt
We determined the molecular mechanism of cell death response by MutS homologs in distinction to the repair event. Key protein-DNA contacts differ in the interaction of MutS homologs with cisplatinated versus mismatched DNA. Mutational analyses of protein-DNA contacts, which were predicted by molecular dynamics (MD) simulations, were performed. Mutations in suggested interaction sites can affect repair and cell...
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