Mutations in the conserved glycine and serine of the MutS ABC signature motif affect nucleotide exchange, kinetics of sliding clamp release of mismatch and mismatch repair.

Abstract excerpt

The MutS protein controls genomic stability by coordinating recognition and repair of DNA mismatches with ATP utilization. The nature of this coordination is unclear. This study demonstrates the importance of a highly conserved flexible loop found in Escherichia coli MutS (residues 658-670) in DNA mismatch repair. This loop is speculated to be analogous to the ABC signature motif of drug transporters based on its...

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• Adenosine Triphosphatases
• ATP-Binding Cassette Transporters
• DNA Mismatch Repair
• Escherichia coli Proteins
• Glycine