Article
Dynamics of MutS-mismatched DNA complexes are predictive of their repair phenotypes.
Biochemistry - 1 Apr 2014
DeRocco Vanessa C, Sass Lauryn E, Qiu Ruoyi, Weninger Keith R, Erie Dorothy A
Abstract excerpt
MutS recognizes base-base mismatches and base insertions/deletions (IDLs) in newly replicated DNA. Specific interactions between MutS and these errors trigger a cascade of protein-protein interactions that ultimately lead to their repair. The inability to explain why different DNA errors are repaired with widely varying efficiencies in vivo remains an outstanding example of our limited knowledge of this process....
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