Article
Wot the 'L-Does MutL do?
Mutation research - 1 Dec 2010
Polosina Yaroslava Y, Cupples Claire G
Abstract excerpt
In model DNA, A pairs with T, and C with G. However, in vivo, the complementarity of the DNA strands may be disrupted by errors in DNA replication, biochemical modification of bases and recombination. In prokaryotic organisms, mispaired bases are recognized by MutS homologs which, together with MutL homologs, initiate mismatch repair. These same proteins also participate in base excision repair and nucleotide...
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