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MutL: conducting the cell's response to mismatched and misaligned DNA

1 Dec 2009

Abstract excerpt

Base pair mismatches in DNA arise from errors in DNA replication, recombination, and biochemical modification of bases. Mismatches are inherently transient. They are resolved passively by DNA replication, or actively by enzymatic removal and resynthesis of one of the bases. The first step in removal is recognition of strand discontinuity by one of the MutS proteins. Mismatches arising from errors in DNA...

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PMID: 19953589
DOI: 10.1002/bies.200900089

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