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Article

The non-structural 5A protein of hepatitis C virus exhibits genotypic differences in interferon antagonism.

Journal of hepatology - 1 Dec 2008

Tsai Ya-Hui, Kuang Wan-Fen, Lu Tsai-Yi, Kao Jia-Horng, Lai Ming-Yang, Liu Chun-Jen, Chen Pei-Jer, Hwang Lih-Hwa

Abstract excerpt

BACKGROUND/AIMS: Patients infected with hepatitis C virus (HCV) genotype 2 or 3 usually respond better to interferon (IFN) treatment than those infected with genotype 1. In this study, we investigated whether the non-structural 5A protein (NS5A) of HCV genotypes 1 and 2 (1b-NS5A and 2a-NS5A, respectively) exerted differential counteractivities against IFN treatment. METHODS: We compared the inhibitory effects of...

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Identifiers

PMID: 18842320
DOI: 10.1016/j.jhep.2008.06.030

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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