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Regulation of PKR and IRF-1 during hepatitis C virus RNA replication

19 Mar 2002

Abstract excerpt

The virus-host interactions that influence hepatitis C virus (HCV) replication are largely unknown but are thought to involve those that disrupt components of the innate intracellular antiviral response. Here we examined cellular antiviral pathways that are triggered during HCV RNA replication. We report that (i) RNA replication of HCV subgenomic replicons stimulated double-stranded RNA (dsRNA) signaling pathways...

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PMID: 11904369
DOI: 10.1073/pnas.062055699

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