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Article

Replicons from genotype 1b HCV-positive sera exhibit diverse sensitivities to anti-HCV reagents.

Antiviral research - 1 Apr 2009

Nishimura Go, Ikeda Masanori, Mori Kyoko, Nakazawa Takahide, Ariumi Yasuo, Dansako Hiromichi, Kato Nobuyuki

Abstract excerpt

Half of the population of genotype 1 HCV is resistant to current pegylated-interferon-alpha (PEG-IFN-alpha) and ribavirin therapy. The resistance to IFN therapy is an urgent problem, especially in patients with genotype 1 HCV infection. However, sensitivities among HCV strains to anti-HCV reagents including IFNs have not been thoroughly addressed. Here, we established three different subgenomic replicons (1B-4,...

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Source

Identifiers

PMID: 19428594
DOI: 10.1016/j.antiviral.2009.01.007

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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