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Article

Control of temporal activation of hepatitis C virus-induced interferon response by domain 2 of nonstructural protein 5A.

Journal of hepatology - 1 Oct 2015

Hiet Marie-Sophie, Bauhofer Oliver, Zayas Margarita, Roth Hanna, Tanaka Yasuhito, Schirmacher Peter, Willemsen Joschka, Grünvogel Oliver, Bender Silke, Binder Marco, Lohmann Volker, Lotteau Vincent, Ruggieri Alessia, Bartenschlager Ralf

Abstract excerpt

BACKGROUND & AIMS: Hepatitis C virus (HCV) nonstructural protein 5A (NS5A) is a multifunctional protein playing a crucial role in diverse steps of the viral replication cycle and perturbing multiple host cell pathways. We showed previously that removal of a region in domain 2 (D2) of NS5A (mutant...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 25908268
DOI: 10.1016/j.jhep.2015.04.015

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-25908268-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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