Article
The molecular basis for responsiveness to anti-viral therapy in hepatitis C.
Forum (Genoa, Italy) - 1 Jan 2000
Polyak S J, Gerotto M
Abstract excerpt
Hepatitis C virus (HCV) infection is an important clinical problem, with a world-wide prevalence of approximately 1-2%. HCV infection is associated with an increased risk for the development of severe liver disease. HCV is inherently resistant to anti-viral therapy with interferon (IFN). The virus circulates in infected individuals as a mixture of related, yet genetically distinct variants, or quasispecies. Many...
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