Article
Mutations in the NS5B region of the hepatitis C virus genome correlate with clinical outcomes of interferon-alpha plus ribavirin combination therapy.
Journal of gastroenterology and hepatology - 1 Sept 2005
Hamano Kosei, Sakamoto Naoya, Enomoto Nobuyuki, Izumi Namiki, Asahina Yasuhiro, Kurosaki Masayuki, Ueda Eri, Tanabe Yoko, Maekawa Shinya, Itakura Jun, Watanabe Hideki, Kakinuma Sei, Watanabe Mamoru
Abstract excerpt
BACKGROUND AND AIM: Combination treatments of interferon-alpha (IFN) and ribavirin (RBV) are more effective than those of IFN alone in hepatitis C virus (HCV) infection. However, mechanisms of the action of the combination regimen are not well understood. To elucidate the viral genetic basis of IFN plus RBV combination therapy, genetic variabilities of HCV-1b were analyzed. METHODS: We performed pair-wise...
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