Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prospective characterization of full-length hepatitis C virus NS5A quasispecies during induction and combination antiviral therapy.

Journal of virology - 1 Oct 2000

Nousbaum J, Polyak S J, Ray S C, Sullivan D G, Larson A M, Carithers R L, Gretch D R

Abstract excerpt

The hepatitis C virus (HCV) nonstructural 5A (NS5A) protein has been controversially implicated in the inherent resistance of HCV to interferon (IFN) antiviral therapy in clinical studies. In this study, the relationship between NS5A mutations and selection pressures before and during antiviral therapy and virologic response to therapy were investigated. Full-length NS5A clones were sequenced from 20 HCV genotype...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Amino Acid Sequence
Share to Antiviral Agents

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Drug Therapy, Combination

Share to Hepacivirus

Share to Hepatitis C

Share to Interferons

Share to Ribavirin

Share to Viral Nonstructural Proteins

Source

Open in PubMed Open full text

Identifiers

PMID: 10982347
DOI: 10.1128/jvi.74.19.9028-9038.2000
PMCID: PMC102099

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prospective characterization of full-length hepatitis C virus NS5A quasispecies during induction and combination antiviral therapy.PMID 10982347Read ↗

Mutations in the protein kinase-binding domain of the NS5A protein in patients infected with hepatitis C virus type 1a are associated with treatment response.Semantic proximity Read ↗

Quasispecies evolution in NS5A region of hepatitis C virus genotype 1b during interferon or combined interferon-ribavirin therapy.Semantic proximity Read ↗

Analysis of sequence configurations of the ISDR, PKR-binding domain, and V3 region as predictors of response to induction interferon-alpha and ribavirin therapy in chronic hepatitis C infection.Semantic proximity Read ↗

The molecular basis for responsiveness to anti-viral therapy in hepatitis C.Semantic proximity Read ↗

Selection of HCV NS5A quasispecies during IFN therapy in patients with chronic HCV.Semantic proximity Read ↗

Analysis of HCV quasispecies dynamic under selective pressure of combined therapy.Semantic proximity Read ↗

The hepatitis C virus NS5A protein and response to interferon alpha: mutational analyses in patients with chronic HCV genotype 3a infection from India.Semantic proximity Read ↗

Quasispecies of hepatitis C virus genotype 1 and treatment outcome with peginterferon and ribavirin.Semantic proximity Read ↗

Is investigation of hepatitis C virus NS5A gene heterogeneity a tool for predicting long-lasting response to interferon therapy in patients with HCV-1b chronic hepatitis?Semantic proximity Read ↗

Impact of NS5A sequences of Hepatitis C virus genotype 1a on early viral kinetics during treatment with peginterferon- alpha 2a plus ribavirin.Semantic proximity Read ↗

Hepatitis C Virus Nonstructural 5A Protein and Interferon Resistance: a New Model for Testing the Reliability of Mutational AnalysesSemantic proximity Read ↗

Relationship of hepatitis C genotype 1 NS5A sequence mutations to early phase viral kinetics and interferon effectiveness.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.