Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Relationship between the effect of interferon therapy and the change of hepatitis C virus non-structural 5B gene.

Journal of gastroenterology and hepatology - 1 Apr 1999

Horiike N, Michitaka K, Masumoto T, Okura I, Akbar S M, Onji M

Abstract excerpt

BACKGROUND: Hepatitis C virus (HCV)-RNA titre has been regarded as a factor affecting the response to interferon (IFN) therapy of patients with chronic hepatitis C (CHC). The focus of our study is the investigation of the nucleotide sequence of HCV-RNA NS5B, which may code RNA-dependent RNA polymerase and NS5A in the sera of 33 patients with CHC prior to IFN therapy. METHODS: Hepatitis C virus genotype and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antiviral Agents
Share to Genes, Viral

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Hepacivirus

Share to Hepatitis C, Chronic

Share to Interferon-alpha

Share to Interferon alpha-2

Share to Recombinant Proteins

Share to Reverse Transcriptase Polymerase Chain Reaction

Source

Identifiers

PMID: 10207784
DOI: 10.1046/j.1440-1746.1999.01859.x

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Relationship between the effect of interferon therapy and the change of hepatitis C virus non-structural 5B gene.PMID 10207784Read ↗

[Variation in hepatitis C virus NS 5b nucleotide sequence and its relationship with interferon treatment].Semantic proximity Read ↗

Efficacy and changes of the nonstructural 5A GENE by prolonged interferon therapy for patients with hepatitis C virus genotype 1b and a high level of serum HCV-RNA.Semantic proximity Read ↗

Mutations in the nonstructural protein 5A gene and response to interferon in patients with chronic hepatitis C virus 1b infection.Semantic proximity Read ↗

Mutations in the NS5B region of the hepatitis C virus genome correlate with clinical outcomes of interferon-alpha plus ribavirin combination therapy.Semantic proximity Read ↗

The non-structural 5A protein of hepatitis C virus exhibits genotypic differences in interferon antagonism.Semantic proximity Read ↗

Relationship between interferon therapy and variability in nonstructural gene 5b of hepatitis C virus.Semantic proximity Read ↗

The mutations in ISDR of NS5A gene are not associated with response to interferon treatment in Turkish patients with chronic hepatitis C virus genotype 1b infection.Semantic proximity Read ↗

Quasispecies evolution in NS5A region of hepatitis C virus genotype 1b during interferon or combined interferon-ribavirin therapy.Semantic proximity Read ↗

Mutations in the nonstructural 5A region of hepatitis C virus and response of chronic hepatitis C to interferon alfa.Semantic proximity Read ↗

Mutations in nonstructural protein 5A gene and response to interferon in hepatitis C virus genotype 2 infection.Semantic proximity Read ↗

Mutations in ISDR of NS5A gene influence interferon efficacy in Chinese patients with chronic hepatitis C virus genotype 1b infection.Semantic proximity Read ↗

Comparison of full-length sequences of interferon-sensitive and resistant hepatitis C virus 1b. Sensitivity to interferon is conferred by amino acid substitutions in the NS5A region.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.