Article
Mutations in the interferon sensitivity-determining region (nonstructural 5A amino acid 2209-2248) in patients with hepatitis C-1b infection and correlating response to combined therapy of pegylated interferon and ribavirin.
Alimentary pharmacology & therapeutics - 1 Jan 2008
Yen Y-H, Hung C-H, Hu T-H, Chen C-H, Wu C-M, Wang J-H, Lu S-N, Lee C-M
Abstract excerpt
BACKGROUND: Most reports suggest that mutations in the interferon sensitivity-determining region (ISDR) correlate with response to conventional interferon-based therapies in hepatitis C virus-1b (HCV-1b) patients. However, the correlation between ISDR region mutations and response to pegylated interferon plus ribavirin therapy in HCV-1b patients remains unclear. AIM: To assess whether ISDR mutations correlate...
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