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Article

Variability of the nonstructural 5A protein of hepatitis C virus type 3a isolates and relation to interferon sensitivity.

The Journal of infectious diseases - 1 Mar 2002

Castelain Sandrine, Khorsi Hafida, Roussel Juliette, François Catherine, Jaillon Olivier, Capron Dominique, Penin François, Wychowski Czeslaw, Meurs Eliane, Duverlie Gilles

Abstract excerpt

The nonstructural 5A (NS5A) protein of hepatitis C virus (HCV) genotype 1 is thought to interact with several cellular proteins, including the double-stranded RNA-dependent protein kinase (PKR) induced by interferon (IFN). The PKR-binding domain (PKR-BD; aa 2209-2274), including the IFN sensitivity-determining region (aa 2209-2248) and other regions, could be linked to IFN resistance. Thus, the entire NS5A...

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PMID: 11865413
DOI: 10.1086/339051

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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